منابع مشابه
Does gastric aminopyrine clearance reflect gastric mucosal blood flow or parietal cell function?
Gastric aminopyrine clearance was measured in human volunteers and dogs with untreated basal secretion, in human volunteers and dogs treated with secretory inhibitors, in dogs treated with histamine, and in patients with pernicious anaemia. When aminopyrine was given as a bolus to man or dog, aminopyrine clearance and the ratio aminopyrine concentration in gastric juice/aminopyrine concentratio...
متن کاملAssessment of the (14C) aminopyrine breath test in liver disease.
Different methods of performing the (14C) aminopyrine breath test have been assessed. A tracer dose of 2 muCi without a loading dose and with a single breath collection at two hours was the method selected, since it gave the best discrimination between patients with hepatocellular diseases and normal subjects (5.2 +/- 0.2%, mean +/- SEM). Reduced values occurred in patients with chronic active ...
متن کاملAntiarrhythmic action of metiamide in experimental cardiac arrhythmias.
It has been well established that cardiac actions of histamine are mediated by histamineHI and H2 receptors and that there exist specific agonists and antagonists acting on them (1.2.3:4.5.7.8 and 11). Cyclizine. an antihistamine has been shown to antagonize positivechronotropic effect of histamine which is mediated through H2 receptors (8) and to possessantiarrhythmic effect in experiernntal c...
متن کاملEnzymatic dealkylation of aminopyrine (pyramidon) and other alkylamines.
Many drugs which are alkylamines undergo dealkylation in the body. For example aminopyrine (2), ephedrine (3), codeine (4), meperidine (5, S), methylamphetamine (7), and mephobarbital (8, 9) are all demethylated in ti~o. The removal of ethyl groups has been demonstrated with quinacrine,’ and an unusual t,ype of dealkylation, the loss of a B-chloroethyl group, occurs in the biotransformation of ...
متن کاملHepatic aminopyrine N-demethylase system: further studies of assay procedure.
Rat hepatic aminopyrine N-demethylase activity was measured by detecting the amount of formaldehyde produced from aminopyrine. Some optimal conditions for the N-demethylation were determined using both isolated microsomes and whole homogenates, and the standard assay method is described. Formaldehyde production from the substrate by microsomal enzyme system was linear to the amount of microsome...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1975
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(75)80031-x